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ABCA1 upregulation and the inhibition of cardiolipin peroxidation both significantly impaired DN progression and ameliorated podocyte damage, while SS-31 reduced cardiolipin oxidation, thereby decreasing proteinuria, mesangial expansion, and podocyte deficiency in ABCA1-deficient ob/ob mice [51]

An approach targeting the androgenAR axis at different levels could, therefore, improve the efficacy of prostate cancer therapy

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Research focus: Appetite/satiety signaling, weight management, and complementary effects alongside GLP-1 receptor agonism

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